Makiko Shimizu Selected Research

FI-700

8/2007

A novel FLT3 inhibitor FI-700 selectively suppresses the growth of leukemia cells with FLT3 mutations.

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Makiko Shimizu Research Topics

Disease

16	Trimethylaminuria 12/2021 - 06/2006
9	Asthma (Bronchial Asthma) 04/2007 - 09/2004
6	Body Weight (Weight, Body) 10/2021 - 05/2015
6	Neoplasms (Cancer) 07/2021 - 08/2007
3	Infections 07/2022 - 01/2006
3	Dyslipidemias (Dyslipidemia) 09/2019 - 01/2016
3	Hypertension (High Blood Pressure) 09/2019 - 01/2016
2	Breast Neoplasms (Breast Cancer) 08/2022 - 01/2018
2	Poisoning 08/2021 - 01/2020
2	Arteriosclerosis 06/2021 - 01/2020
2	Drug Overdose 02/2021 - 01/2020
2	Prediabetic State (Prediabetes) 01/2021 - 11/2018
2	Wounds and Injuries (Trauma) 12/2020 - 12/2014
2	Liver Cirrhosis (Hepatic Cirrhosis) 12/2020 - 09/2020
2	Inborn Genetic Diseases (Disease, Hereditary) 08/2020 - 10/2019
2	Respiratory Insufficiency (Respiratory Failure) 11/2019 - 01/2018
2	Abdominal Obesity 09/2018 - 09/2017
2	Atherosclerosis 01/2017 - 03/2015
2	Type 2 Diabetes Mellitus (MODY) 04/2015 - 10/2014
2	Leukemia 08/2009 - 08/2007
1	Knee Osteoarthritis 07/2022
1	Adenomatous Polyposis Coli (Familial Adenomatous Polyposis) 07/2021
1	Colorectal Neoplasms (Colorectal Cancer) 07/2021
1	Anemia 05/2020
1	Attention Deficit Disorder with Hyperactivity (Attention Deficit Hyperactivity Disorder) 04/2020
1	Atrial Fibrillation 09/2019
1	Cough 01/2018
1	Exanthema (Rash) 01/2018
1	Hyperglycemia 01/2018
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 09/2017
1	Diabetes Complications 01/2016

Drug/Important Bio-Agent (IBA)

17	dimethylaniline monooxygenase (N-oxide forming) (flavin-containing monooxygenase)IBA 12/2021 - 06/2006
12	trimethylamineIBA 06/2021 - 01/2007
6	EnzymesIBA 07/2021 - 06/2007
5	trimethyloxamine (trimethylamine N-oxide)IBA 06/2021 - 01/2009
5	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 10/2014
4	Pharmaceutical PreparationsIBA 08/2021 - 04/2015
3	Proteins (Proteins, Gene)FDA Link 08/2022 - 07/2005
3	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 07/2021 - 02/2015
3	Immunoglobulin E (IgE)IBA 01/2006 - 09/2004
2	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 08/2022 - 09/2019
2	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 07/2021 - 06/2005
2	Glycated Hemoglobin (Glycosylated Hemoglobin)IBA 01/2021 - 09/2018
2	Messenger RNA (mRNA)IBA 12/2020 - 02/2007
2	Fluconazole (Zonal)FDA LinkGeneric 12/2020 - 12/2005
2	(R)-2-(3-((benzoxazol-2-yl-d4 (3- (4- methoxyphenoxy- d7)propyl)amino)methyl)phenoxy) butanoic acidIBA 12/2020 - 09/2020
2	Cytochrome P-450 CYP2D6 (CYP2D6)IBA 04/2020 - 01/2018
2	edoxabanIBA 01/2020 - 09/2019
2	Biomarkers (Surrogate Marker)IBA 01/2020 - 01/2018
2	dihydrocodeine FDA LinkGeneric 11/2019 - 01/2018
2	Phosphates (Orthophosphate)IBA 11/2019 - 01/2018
2	Nonsense Codon (Nonsense Mutation)IBA 10/2019 - 06/2007
2	Carnitine (L-Carnitine)FDA LinkGeneric 01/2017 - 03/2015
2	OxidesIBA 05/2014 - 06/2007
2	DNA (Deoxyribonucleic Acid)IBA 11/2012 - 01/2007
2	CytokinesIBA 04/2007 - 11/2005
2	EndotoxinsIBA 03/2006 - 01/2006
1	Pregnancy-Associated Plasma Protein-A (PAPP-A)IBA 08/2022
1	LY 165163 (PAPP)IBA 08/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 07/2022
1	Linezolid (Zyvox)FDA Link 07/2022
1	Oxazolidinones (2 Oxazolidone)IBA 07/2022
1	Caffeine (No Doz)FDA LinkGeneric 10/2021
1	loxoprofen (CS 600)IBA 09/2021
1	TabletsIBA 09/2021
1	Diphenhydramine (Benadryl)FDA LinkGeneric 08/2021
1	Histamine H1 Receptors (Histamine H1 Receptor)IBA 08/2021
1	Duloxetine Hydrochloride (Cymbalta)FDA Link 02/2021
1	Human Serum Albumin FDA LinkGeneric 12/2020
1	bromobenzeneIBA 12/2020
1	1,4-dibromobenzeneIBA 12/2020
1	1,2-dibromobenzeneIBA 12/2020
1	Clopidogrel (Plavix)FDA Link 12/2020
1	Clarithromycin (Biaxin)FDA LinkGeneric 12/2020
1	Rifampin (Rifampicin)FDA LinkGeneric 09/2020
1	sacubitrilIBA 09/2020
1	Hemoglobins (Hemoglobin)IBA 05/2020
1	Atomoxetine Hydrochloride (Strattera)FDA LinkGeneric 04/2020
1	XenobioticsIBA 10/2019
1	Dabigatran FDA Link 09/2019
1	apixabanIBA 09/2019
1	AnticoagulantsIBA 09/2019
1	RivaroxabanIBA 09/2019
1	CreatinineIBA 09/2019
1	Letrozole (Femara)FDA LinkGeneric 01/2018
1	Aromatase (CYP19)IBA 01/2018
1	KW-2450IBA 01/2018
1	Lapatinib (GW572016)FDA Link 01/2018
1	DihydromorphineIBA 01/2018
1	Drug CombinationsIBA 01/2018
1	Hormones (Hormone)IBA 01/2018
1	human ERBB2 proteinIBA 01/2018
1	afimoxifene (hydroxytamoxifen)IBA 01/2018
1	oxidized low density lipoproteinIBA 01/2016
1	Receptor Protein-Tyrosine Kinases (Tyrosine Kinase Receptors)IBA 01/2016

Therapy/Procedure

4	Oral Administration 12/2020 - 08/2007
2	Intravenous Infusions 07/2022 - 09/2003
2	Intravenous Administration 05/2015 - 05/2009
1	Chemoprevention 07/2021
1	Glycemic Control 01/2016